Azelaic acid, a dicarboxylic acid has gained significant attention in various industries.
Product Performance Table
Property | Details |
Physical State | White to off-white crystalline powder. |
Melting Point | 106 - 108 °C. |
Solubility | Slightly soluble in water (approx. 2.4 g/L at 25 °C), soluble in ethanol and ether. |
Acidity (pKa) | 4.56 and 5.49. |
Antimicrobial Activity | Demonstrates inhibitory effects against various microorganisms, including Propionibacterium acnes, with minimum inhibitory concentrations (MIC) ranging from 0.5% to 3% depending on the strain. |
Applications
· In the pharmaceutical industry, it is used in the treatment of acne vulgaris. Clinical trials have shown that topical application of 15% - 20% azelaic acid formulations can reduce the number of comedones, papules, and pustules by approximately 30% - 60% after 12 - 16 weeks of use.
· In the cosmetic field, it is utilized for skin lightening and hyperpigmentation treatment. It inhibits the activity of tyrosinase, an enzyme involved in melanin synthesis. Studies indicate that a 2% azelaic acid formulation can reduce melanin content in the skin by around 10% - 15% after 8 - 12 weeks.
Safety Considerations
Azelaic acid is generally considered safe for topical use. However, some individuals may experience mild skin irritation, erythema, or peeling, especially during the initial application phase. The incidence of such side effects is relatively low and usually subsides with continued use.
Product Images
In conclusion, azelaic acid offers a range of beneficial properties and applications, making it a valuable ingredient in both pharmaceutical and cosmetic formulations.
